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Semaglutide Intermediate P29 (GLP-1(9-37))

CAS.NO: 1169630-82-3

Cat.No:P806

Storage conditions: -15℃ below, protected from light, sealed


Semaglutide Intermediate 29 Peptide, also known as Semaglutide 29 peptide main chain, Semaglutide Intermediate P29 or GLP-1(9-37), is the key intermediate of the synthesis of Semaglutide API.


Insulin Degludec

Semaglutide Intermediate P29 (GLP-1(9-37)) Specifications

ItemsCharacteristic
SourceE.Coli
AppearancesWhite or off-white lyophilized powder
SolubilitySoluble in water (pH11.0-pH11.5)
Purity≥90.0%
Loss on drying≤10.0%
ContentCalculated on a dry basis, the content of semaglutide intermediate 29 peptide should be ≥ 90.0%

The data should be subject to test report of products.


Semaglutide Intermediate P29 (GLP-1(9-37)) Description

Semaglutide Intermediate 29 Peptide, also known as Semaglutide 29 peptide backbone, Semaglutide Intermediate P29 or GLP-1(9-37), is the key intermediate of the synthesis of Semaglutide API.

 

Semaglutide is a 2nd  Generation GLP-1RA drug. In Dec., 2019, Semaglutide injection (brand name: Ozempic, 4mg/3ml) was approved by FDA to improve glycemic control in adults with type 2 diabetes. In Jun. 2021, Semaglutide injection (brand name Wegovy, 2.4mg/dose) was approved by FDA to treat obesity (BMI>30kg/m2) and overweight (BMI≥27kg/m2).


In Sep. 2019, oral Semaglutide (brand name, Rybelsus, 3ma, 7mg and 14ma/ tablet) was approved by FDA for the treatment of type 2 diabetes. Meanwhile, Rybelsus 25mg and 50mg strengths showed clear effects in Phase II and Phase III clinical trials for weight loss or non-alcoholic fatty liver (NASH). In Oct., 2023, phase II clinical trials for patients with insufficiency type II diabetes and chronic kidney disease were terminated early due to excellent efficacy.


Gene-Biocon Semaglutide intermediate P29 (GLP- 1(9-37))  is produced by genetic engineering fermentation. The production process is carried out under GMP conditions and the product purity is high. This product is a lyophilized powder obtained by enzyme cleavage, chromatography purification and freeze drying of the Semaglutide precursor expressed

by Escherichia coli. It has been supplied on a commercial scale and can be packaged and customized according to customer requirements.


Semaglutide Intermediate P29 (GLP-1(9-37)) Advantage

  • Animal-free: no animal viruses, no pathogenic substances or exogenous factor contamination, highly safe.


  • Meet the requirements of GMP specification.


  • Complete quality documents.


Semaglutide Intermediate P29 (GLP-1(9-37)) Usage

For the production of Semaglutide.


Semaglutide Intermediate P29 (GLP-1(9-37)) Recommended Method

Take an appropriate amount of this product and dissolve it in purified water to make the concentration of Semaglutide  Intermediate P29 5-10mg/ml, adjust the pH to 11.0-11.5 to dissolve and clarify. Optimize the reaction system and synthesize Semaglutide.


Semaglutide Intermediate P29 (GLP-1(9-37)) Transport and Storage Stability

  • Transportation stability: It is transported in an ice pack to keep it active.


  • Storage stability: It can be stored stably for 24 months at -15℃ or below in a sealed and dark place.


Notice and Disclaimer


  • Avoid long time storage in liquid condition, please use it as soon as possible once it was dissolved.


  • Avoid strong acids, strong bases, strong oxidants, high concentrations of organic solvents and other reagents that can easily cause protein denaturation.


  • The product is for research and production only and should not be used for diagnosis or treatment of animals or humans.

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All products from the site for Research Use Only. Not for use in diagnostic procedures. Reproduction of any materials is strictly forbidden without permission.